Science & Enterprise subscription

Follow us on Twitter

  • A lab studying DNA from past civilizations and the genomics technology company Illumina are investigating remains o… https://t.co/9QAzyMnN3T
    about 2 hours ago
  • New post on Science and Enterprise: Ancient DNA Studied for Mental Health Clues https://t.co/dgAigusqOt #Science #Business
    about 2 hours ago
  • A smartphone app is being developed to help pregnant women and new mothers with an opioid addiction, by a medical p… https://t.co/6YA7lUJnMu
    about 6 hours ago
  • New post on Science and Enterprise: App Created for New, Pregnant Moms in Opioid Recovery https://t.co/Zu5igRQQwk #Science #Business
    about 6 hours ago
  • A start-up company spun-off from Cornell University is receiving a small business grant to develop in crop plants a… https://t.co/oU7iBAy0Uo
    about 1 day ago

Please share Science & Enterprise

RSS
Follow by Email
Facebook
Facebook
Google+
Twitter
Visit Us
LinkedIn
INSTAGRAM

Fund Established to Develop Cancer Vaccines

Loose bills of multiple=Cancer Research Institute (CRI) a not-for-profit organization in New York to advance the science of tumor immunology and discover new cancer therapies, launched today the Cancer Vaccine Acceleration Fund (CVAF), a new model of philanthropic investment and academic-industry collaboration. CRI established the fund with the Ludwig Institute for Cancer Research to encourage development of therapeutic cancer vaccines and other immune system-based therapies.

Therapeutic cancer vaccines harness one’s own immune system to recognize and attack cancer cells throughout the body. Clinical trials have provided evidence that therapeutic vaccines can help patients stabilize their existing cancers, achieve tumor regressions, and delay or prevent cancer recurrence. Despite this promise, says CRI, therapeutic cancer vaccine developers have not yet realized the potential of this new class of treatment.

An analysis of the field two years ago by CRI identified two major challenges to the rapid development of cancer vaccines:

  • Developing cancer vaccines is a complex undertaking because they must incorporate multiple components that acting together to be effective against cancer.
  • The funding gap for early phase clinical trials is large and getting larger, particularly for treatments considered more complex or riskier than average, such as cancer immunotherapy.

CRI says it created the Cancer Vaccine Acceleration Fund to overcome these challenges. CVAF uses a selective screening process to identify and prioritize the most promising cancer vaccines and vaccine components in global development. The fund then seeks out partnerships with pharmaceutical companies to bring these therapies into well-designed clinical trials, where they can be studied in depth and where potentially complementary immunotherapies can be identified.

Like any investor, CVAF seeks to structure its investments to generate a significant return on investment back to CRI if potential therapies supported by CVAF successfully obtain FDA approval. CRI says such returns will be reinvested in additional cancer vaccine clinical trials, helping the program to become self-sustaining.

In addition to funding, CVAF also offers to its partners the clinical trial expertise of the Ludwig Institute for Cancer Research, which has designed and managed immunotherapy clinical trials for more than a decade.

CVAF has collaborations in place with pharmaceutical companies developing two immunotherapies, Tolerx, Inc., a biotechnology company in Cambridge, Massachusetts, to support a phase 1 clinical trial of TRX518, an anti-GITR (glucocorticoid-induced tumor necrosis factor receptor)monoclonal antibody. Tolerx designed TRX518 to enhance the immune system by enabling T cells to attack cancer cells more effectively.

The fund estimates $40 million is needed over the next five years to support four to five early phase clinical trials per year. CRI has pledged to contribute $15 million toward that goal. Of the remaining $25 million to be raised, the fund has already secured $7.5 million in five-year commitments from a group of founding directors.

Related:

Photo: borman818/Flickr

*     *     *

Please share Science & Enterprise ...

3 comments to Fund Established to Develop Cancer Vaccines