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U.S. Patent Filed for Vein Regeneration Technology

USPTO building (USPTO.gov)

(USPTO.gov)

Pall Corporation in Port Washington, New York has applied for a patent with the U.S. Patent and Trademark Office (USPTO) for a disposable, closed cell collection and seeding system developed for vein regeneration procedures. The system, according to Pall Corp., offers a method for isolating and collecting a patient’s mononuclear cells, which are then seeded onto a biocompatible scaffold or tissue graft for implantation into that patient.

The Pall Corp. technology aims to speed the process of isolating and delivering cells to an engineered vascular graft that can be implanted in a patient, and become a major blood vessel returning blood to the heart. The system is being developed for implanting bioengineered grafts in patients with congenital heart defects to replace damaged or missing blood vessels.

Because the system is self-contained and pre-connected, says Byron Selman, president of Pall Medical, “the entire process can be started and completed right next to the operating table,” without the need for a clean room and limiting the possibility of contamination. The new blood vessel then grows with the patient.

The technology is expected to support increasing demands of an aging population for procedures such as coronary artery bypass grafting. In these procedures, the challenge is the lack of available blood vessels to serve as replacement arteries, especially with patients in repeat operations where the large veins of the leg have already been used and are no longer available.

Pall Corp’s technology was among those discussed in an article that appeared in the 7 September 2011 issue of Nature Medicine.

Read more: Patients Get Lab-Grown Blood Vessels From Donor Skin Cells

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