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Patent Awarded for Drug Spray/Dispersion Technology

Bend Research Inc., a developer of drug formulation technology in Bend, Oregon, says it received a U.S. patent covering a process for making spray-dried solid amorphous dispersions of drugs using pressure nozzles.

The patent — No. 7,780,988 assigned by the U.S. Patent and Trademark Office — covers a spray-drying process for producing solid amorphous dispersions from drugs with low aqueous solubility and polymers. The resulting formulations can for many patients increase the amount of drug that is orally absorbed when administered.

The company says the patent addresses a common problem with conventional spray-drying processes: the production of very small particles known as “fines.” These fines often impede the flow of dispersions with conventional processes, and are difficult to collect efficiently and formulate into solid dosage forms. The technology covered by this patent makes it possible to produce larger particles with fewer fines, improving particle flow, creating more efficient collections, and simplifying downstream handling and processing.

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