Science & Enterprise subscription

Follow us on Twitter

  • As the U.S. enters its Independence Day in the midst of its worst-ever pandemic, a divided public most trusts its h… https://t.co/umw9fDWuvJ
    about 1 day ago
  • New post on Science and Enterprise: Infographic – Health Agencies Trusted for Covid-19 Info https://t.co/RerieMYQgn #Science #Business
    about 1 day ago
  • Change the name of the Washington NFL team? A respondent to @joshtpm has a brilliant idea ... Washington Dukes, for… https://t.co/J9P4LKG2PT
    about 2 days ago
  • A medical software team designed a mobile app that records and analyzes a person's sounds and sleep positions to de… https://t.co/NB99HQUWpC
    about 2 days ago
  • New post on Science and Enterprise: Mobile App Screens for Sleep Apnea https://t.co/N8gTn2zWhe #Science #Business
    about 2 days ago

Please share Science & Enterprise

Weill Cornell, Tres Cantos Lab to Research TB Chemistry

Mycobacterium tuberculosis bacteria (CDC)

Mycobacterium tuberculosis bacteria (CDC)

Weill Cornell Medical College in New York will provide a microbiologist to work at Tres Cantos Open Lab, a facility of GlaxoSmithKline in Spain, to identify the ability of chemical compounds to penetrate the Mycobacterium tuberculosis bacteria. Financial aspects of the two-year project, funded by the Tres Cantos Open Lab Foundation, were not disclosed.

The Mycobacterium tuberculosis causes tuberculosis (TB) infections, which most commonly affect the lungs. The bacteria are transmitted from person to person through droplets from the throat and lungs of people with the active respiratory disease. Symptoms of active TB of the lung are coughing, sometimes with sputum or blood, chest pains, weakness, weight loss, fever, and night sweats.

The Open Lab project aims to chemical principles that could transform potential chemical inhibitors of tuberculosis bacteria into active drugs, which has become a bottleneck in current anti-infection drug research. Weill Cornell is providing Saki Raheem, one of its a post-doctoral researchers, to study the accumulation of potential drug compounds inside tuberculosis bacteria cells, indicating the associations between cell permeability and anti-TB activity.

Tres Cantos Open Lab is located at GlaxoSmithKline’s (GSK’s) Tres Cantos Medicines Development Campus in Spain. Raheem is expected to work with GSK researchers to apply metabolomics technology developed by Weill Cornell that indicates the chemical signatures of various cellular processes. He will apply the technology to screen and analyze hundreds of potential anti-tuberculosis compounds from GSK’s compound library, aiming for a better description of the physical chemistry needed to penetrate tuberculosis bacteria.

This new research is based on work by Weill Cornell professor and infectious disease specialist Kyu Rhee, who also serves as principal investigator of this project. In November, Rhee and colleagues published research demonstrating the use of current mass spectrometry technologies to visually track the action of antibiotics on living, intact bacterial cells. The technology made it possible to witness biochemical actions of various TB drugs inside tuberculosis bacteria.

“With mass spectrometry, and now the latest metabolomics assay we developed and are testing,” says Rhee, “we aim to design and test the much-needed next generation of effective anti-TB agents.”

Read more:

*     *     *

Please share Science & Enterprise ...

Comments are closed.